The visitors threatened first at Kenilworth Road as Ryan Yates sent a header goalwards from Carl Dickinson's delivery but Marek Stech deflected the ball over the bar before the midfielder poked the ensuing corner wide.
Notts continued to threaten, with Jon Stead latching on to Terry Hawkridge's cross before holding off his defender and rolling the ball straight at the Hatters goalkeeper.
Stead then had another chance after outmuscling Alan Sheehan to bring down the ball in the channel before cutting infield on his left foot, but once again Stech was equal to the effort.
However, Luton went on to take the lead against the run of play on 26 minutes with their first shot on target.
Sheehan sent a corner kick to the far post, where Johnny Mullins was perfectly placed to plant a downward header beyond Ross Fitzsimons to send the crowd barmy.
Jorge Grant looked for an immediate reply, shooting at Stech, but the pendulum swung back towards the hosts before Notts finished the half strongly, albeit a goal behind.
Luton made a better start to the second half, Danny Hylton turning his marker and seeing his ensuing effort charged down.
County then threatened as Matt Tootle's cross headed over by Grant, while Yates pounced on a loose ball to sidefoot wide from the edge of the area.
Kevin Nolan's side were able to find an equaliser when Mullins gave away a free kick on the hour mark, which Grant whipped into the box where Shola Ameobi was on hand to nod into the goal.
Fitzsimons was the hero late on as he made a wonderful save from point-blank range against Mullins as the final whistle saw a share of the spoils.
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